Description

Cytotoxic drugs (sometimes known as antineoplastics) describe a group of medicines that contain chemicals which are toxic to cells, preventing their replication or growth, and so are used to treat cancer. They can also be used to treat a number of other disorders such as rheumatoid arthritis and multiple sclerosis. Once inside the body, their action is not generally tightly targeted, and they can produce side effects both to the patients and others who become exposed. This book describes cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors. There are detailed instructions and extensive troubleshooting tips that allow researchers effectively to study a wide variety of drug resistance mechanisms. Each method is designed to help identify the correlation between molecular and biochemical data and the clinical responses of the patient. The methods presented in this book are powerful tools for investigating all the clinically relevant mechanisms used as markers of the biological response to anticancer chemotherapeutics today. This book will give immense pleasure to the reader and is a good companion to the students and research scholars alike.